Clinical Trials

The Vibrance-1 Study for Narcolepsy Type 1 is Now Enrolling
NOW RECRUITING people diagnosed with narcolepsy type 1 (NT1) aged 18 to 70 (click here).
The purpose of this study is to research the safety and effectiveness of an investigational study drug taken orally once daily and how it may work in adults with NT1. Individuals with NT1 may be eligible for the Vibrance-1 Study.
Orexin is a chemical in the brain that helps regulate the sleep/wake cycle. The investigational study drug, ALKS 2680, is an orexin-2 receptor agonist and may improve symptoms of sleep disorder, such as excessive daytime sleepiness (EDS) and cataplexy, in patients with NT1.
Individuals will be evaluated by the study team to determine their eligibility to participate in this research. Each individual who qualifies will receive either the study drug or a placebo, as well as study-related medical exams and study-related laboratory tests, at no cost.
Compensation for time and travel may also be available.
To learn more: Visit VibranceStudies.com
CTR-003484

Interest in Genetic & Blood Markers in Kleine-Levin Syndrome Study
We are seeking volunteers to take part in a research study investigating the genetic basis of KLS. In this study researchers will conduct DNA genetic and blood protein biomarker measurements from blood samples to identify genes associated with KLS. Participation would require that you fill out a questionnaire related to your sleep and KLS symptoms which will be reviewed by our clinical research staff. If you are deemed eligible then you will be asked to donate a blood sample (we will provide instructions and all necessary materials, including financial compensation for sample collection/shipment) which would conclude your active participation in this study.
The investigator on this study is Dr. Emmanuel Mignot and the research staff at the Stanford Center for Narcolepsy and I am the clinical coordinator, Abigail Cirelli. This research study is sponsored by the Kleine-Levin Syndrome Foundation and is conducted at Stanford University.
If you are interested in learning more about the study, please select this link (https://redcap.link/kls_research) in order to review additional information on the study, and verify your interest in participating, and confirm your initial eligibility status. If you have any questions, please feel free to respond to this email and contact me directly at acirelli@stanford.edu.
If the link above does not work, try copying the url below into your web browser:
https://redcap.stanford.edu/surveys/?s=LY3LREWMKC
Thank you for your interest in helping advance research in KLS and please do not hesitate to reach out if you have any questions. We hope you are taking good care of yourself.
Sincerely,
Abigail Cirelli and the KLS Research Team